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What Are the Characteristics of Mephedrone? Mephedrone is a psychoactive drug that incidentally improves mental capacity, physical capacity, or both. It is a synthetic stimulant. It is also known as 4-methylmethcathinone (4-MMC), or 4-methylephedrone, and ought not to be mistaken for methadone, which is a totally different substance. Mephedrone